2. Signaling Pathways
  3. GPCR/G Protein
  4. Urotensin Receptor
  5. Urotensin Receptor Modulator

Urotensin Receptor Modulator

Urotensin Receptor Modulators (2):

Cat. No. Product Name Effect Purity
  • HY-P11258
    UPG-108
    		Modulator
    UPG-108, a peptide compound, is a non-competitive allosteric modulator of Urotensin II receptors (UTR). UPG-108 significantly enhances the efficacy of UTR agonists but reduces the potency of UTR agonists. UPG-111 efficiently induces calcium release and does not cause contraction of rat aortic rings without endothelial denudation. UPG-111 can be used to study various diseases related to the angiotensinergic system.
  • HY-P11259
    UPG-111
    		Modulator
    UPG-111 is a peptide compound that acts as a negative allosteric modulator of the Urotensin II receptor (UTR). UPG-111 exhibits a dual inhibitory effect on the vasoconstriction induced by UTR agonists - it reduces both the maximum response intensity and the sensitivity of the agonist. UPG-111 does not induce calcium release or cause contraction of the endothelium-deprived rat aortic rings. UPG-111 can be used for the study of various diseases related to the angiotensinergic system.